This paper describes an integrated approach to transform an industrial park into an eco-industrial park by combining three interconnected goals, namely, the consolidation of industrial symbiosis, the promotion of sustainable accessibility and the development of multi-functionalities. The result is an interdependent approach where industrial and territorial ecosystems are jointly planned, seeking a more sustainable level of development that considers industrial activity, the transportation of people and goods and the spatial articulation with the neighbouring environment and urban areas. The critical points and challenges for improving the territorial integration of the French industrial park of Salaise-Sablons are discussed, providing lessons for the future. Regardless of the specificities of the case study, this approach has the potential to be adopted in similar industrial parks.