Nowadays, discussion on global cities concept is been addressed at a European level. The concept is a consequence of the array of globalization processes, adding different analysis layers according to social, economic and environmental requirements, such as, cultural, user-friendly and amenity, assessable, sharing, energy, smart, green or city factory age-friendly cities and communities. Cities should also be analyzed as working systems, with the same needs and requirements in terms of safety and well-being that are considered for other systems. Taking this into consideration, the goal of being a Global City should also comprise the so-called occupational layer. Therefore, it is important, within a city context, to define indicators for Sustainability regarding the occupational Layer. This paper aims to develop a methodology helping cities, at a local level, to define an Index for Industry Sustainable development contributing for the global city model.